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Gary Smith

Hello Sir,

We haven't heard on hiv AAV pg9 trial supposed to complete Jan 2016.
Is there any update please?


Richard Jefferys

Hi Gary, it took a long time to hear news from the trial - I just learned this evening that unfortunately none of the nine participants showed detectable levels of the PG9 antibody. The problem appears to relate to the development of antibodies against the PG9 antibody (these were seen in 7 of 9 participants), a problem that has also been seen in animal model studies.

A number of researchers are working to try and solve this problem, particularly the group of Ron Desrosiers, there's a video of a recent presentation by him where he discusses some of the work: https://www.youtube.com/watch?v=JY0MIAPkgmw

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