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Michael Linde

I haven’t read the review, but I have heard a number of different hypotheses for the differences in pathogenesis. The one thing they have in common is that SIV does not cause chronic immune activation. Frank Kirchoff has data showing that SIV nef downregulates CD3, while HIV nef does not. Louis Picker claims that it is a difference in T cell homeostasis, with certain CD4 subsets being depleted. Similarly, Aftab Ansari’s data show differences in T cell activation. I am sure there are many, many other studies out there of which I am unaware. A good review would be helpful in clarifying where all of this research intersects.

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