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Bob Huff

I think the key unanswered question right now is: did they South African DSMB see an interim analysis that confirmed the report from STEP? Even if there was such an early analysis (6 months??) how meaningful could it be?

We seem to have gone from futility to freak-out in a remarkably short time.

Nevertheless, I think it is crucial that volunteers in these studies are followed up thoroughly. Unlike with stopping a drug trial, the vaccine intervention can't be turned off, and endpoints will continue to accumulate.

There may also be a behavioral component to the rate of infections in these trials, and the attention the studies are getting may help reduce those risks.

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