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Regina McEnery

Stay tuned, I guess. NIAID bulletin also noted that the findings in the 503 trial were inconclusive, apparently because the HIV status of 189 participants is unknown at this time. http://www.vaxreport.org/Back-Issues/Pages/old-vaccine-trial-draws-new-scrutiny.aspx. I think NIAID is hosting a meeting in September on ad vectors. Not sure of the date though.

Richard Jefferys

I've heard a date of Sept 19, immediately after the next AVRS. Will add a sentence re: the Phambili caveats (I also forgot to specifically note that it's unblinded follow-up). There's yet another wrinkle in that the enhanced risk in Step is reported to have waned over time, whereas in Phambili it emerged late. The small, non-significant difference post-boost in HVTN 505 also was due to several infections in the vaccine arm that occurred late in the course of follow-up. But despite the confusing aspects of the data I think the overarching concern about three trials, all with findings going in the wrong direction, remains.

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